Nope. Never had a problem from the very beginning, been the most stable DAW I've used. Are you opening a project, i.e. last used? What happens if you use the Start Menu item in the Reaper folder "Reaper(64) Create New Project"?? If you are on Mac, not sure how you use that alternate start option, but someone will surely tell you. Have you just updated? Have you had a Windows update? Sometimes a Windows update can mess with your system audio settings, and set e.g. the default samplerate to 48Khz and change the default audio device. Blame MS for this - happens quite often and messes with many other softwares too! More info required from you of course to help nail this down. Something at your end is not right, else this board would be alight with complaints and mutterings! dB